Inclusion body hepatitis and hydropericardium syndrome (HHS) associated
with fowl adenovirus (FAdV) infections occurred worldwide. In this
study, we confirmed an outbreak of HHS in captive peacocks in Henan
Province, China. The causative agent fowl adenovirus serotype 4 (FAdV-4)
was isolated and designated HN19. Phylogenetic analysis showed that HN19
isolate was clustered in FAdV-C. Animal experiments showed that HN19
exhibited high pathogenicity to chickens. The findings suggested that
the possibility risk of cross-host transmission of FAdV-4.