Kedaling tablets is an extract of with Corydalis yanhusuo W.T. Wang and used to coronary heart disease, angina pectoris, myocardial infarction with no previously well documented hepatotoxicity. We report the first case of kedaling tablets-related drug-induced liver injury (DILI), which highlights the need for clinician awareness regarding potential hepatotoxicity of kedaling tablets, particularly among patients with pre-existing liver disease.