Associations between maternal mid-pregnancy apolipoprotein A-1,
apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm
birth: An observational study
Abstract
Objective: To investigate the association between maternal
apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), ApoB/ApoA-1ratio
and preterm birth (PTB). Design: Observational survey. Setting:
Guangdong Women and Children Hospital, China Samples: 5986 pregnant
women. Method: Data were extracted from the information system of
Guangdong Women and Children Hospital. Maternal serum ApoB, ApoA-1 and
ApoB/ApoA-1 ratio were categorized into tertiles. Logistic regression
models were performed to evaluate the odds ratios and 95% confidence
intervals for PTB. Main outcome measures: PTB (gestational age
< 37 weeks) Results: Of the study participants, the rate of
preterm birth was 5.7% (n= 344). Compare with individuals in the lowest
tertile, the adjusted ORs of PTB was 1.41 (95% CI: 1.07-1.87) for
individuals in the highest tertile of ApoB and 1.35 (95% CI: 1.03-1.78)
for those in the highest tertile of ApoB/ApoA-1. The association of
ApoB/ApoA-1 and PTB was more relevant among women with pre-pregnancy BMI
≤ 24 kg/m2, age at delivery ≥ 35 years or those who were multiparous.
Conclusions: Elevated maternal ApoB level and ApoB/ApoA-1 ratio during
mid-pregnancy were related to increased risk of PTB. Monitoring serum
apolipoprotein levels may help to prevent preterm birth. Funding: The
study was funded by grants 2019FYH003 from Chinese Center for Disease
Control and Prevention. Keywords: Apolipoprotein A-1, Apolipoprotein B,
Apolipoprotein B/Apolipoprotein A-1, Preterm birth Tweetable
abstract:Maternal mid-pregnancy ApoB level and ApoB/ApoA-1 ratio were
associated with PTB.